Tumor Uptake of Anti-CD20 Fabs Depends on Tumor Perfusion
نویسندگان
چکیده
منابع مشابه
Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia
We have previously demonstrated that Tenascin-C (TNC)(+) human neuroblastoma (NB) cells transdifferentiate into tumor-derived endothelial cells (TDEC), which have been detected both in primary tumors and in tumors formed by human NB cell lines in immunodeficient mice. TDEC are genetically unstable and may favor tumor progression, suggesting that their elimination could reduce tumor growth and d...
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BACKGROUND CD20 monoclonal antibodies are widely used in clinical practice. Antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity and direct cell death have been suggested to be important effector functions for CD20 antibodies. However, their specific contributions to the in vivo mechanism of action of CD20 immunotherapy have not been well defined. DESIGN AND METHODS Her...
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A 74-year-old man was referred to the Cardiology clinic with a 3-week history of exertional chest tightness. These episodes lasted a few seconds without any limitation to activity. The gentleman is an ex-smoker and a hypertensive on treatment. The results of the clinical examination and ECG were unremarkable. An exercise tolerance test was found to be negative, albeit at a subtarget heart rate....
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Tumor perfusion and oxygenation status have been suggested as factors which may influence treatment outcome in cancer patients. Nuclear medicine assays of tumor perfusion [99mTc-hexamethylpropylenamine oxime (HMPAO)] and tumor hypoxia [123I-iodoazomycin arabinoside (IAZA)] have recently been developed and described. We report on measurements of perfusion and oxygenation status of 27 tumors in 2...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2016
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.116.176784