منابع مشابه
Tumor Targeting Strategies
Nanoparticle-based drug delivery systems allow improved solubility, enhanced stability in circulation and multi-functionality. These properties and functions open many doors and create new biomedical applications for targeting drugs or imaging agents directly to the disease site. Due to the high incidence and mortality of cancer, studies are concentrating on targeted drug delivery to the tumor....
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Owing to their large size proteinaceous drugs offer higher operative information content compared to the small molecules that correspond to the traditional understanding of druglikeness. As a consequence these drugs allow developing patient-specific therapies that provide the means to go beyond the possibilities of current drug therapy. However, the efficacy of these strategies, in particular "...
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Therapy-resistance and postoperative recurrence are causes of the poor prognosis in pancreatic cancer. Conventional therapies have a limited impact on the control of pancreatic cancer, resulting in the rapid re-growth of the tumor. The indispensable role of tumor-stromal interaction, which acts as a defender of cancer cells and enhances malignant potential, is being uncovered now. For example, ...
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Novel treatment strategies for cancer that are based on a more detailed understanding over the tumor biology are based on the latest new technology and are expected to improve the current treatment outcome for patients with cancer. However, many of these strategies still have one common and critical problem, being their limited specificity for tumor cells. In this context, antibodies against tu...
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Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have be...
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ژورنال
عنوان ژورنال: Journal of Drug Research and Development
سال: 2017
ISSN: 2470-1009
DOI: 10.16966/2470-1009.126