Tumor suppressor p53 meets microRNAs

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Cancer genetics: Tumor suppressor meets oncogene

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The guardian's little helper: microRNAs in the p53 tumor suppressor network.

Several microRNAs (miRNAs) have been implicated in tumor development based on both changes in their expression patterns and gene structural alterations in human tumors. However, we are only now beginning to see how miRNAs interact with classic oncogene and tumor suppressor mechanisms. Several recent studies have implicated the miR-34 family of miRNAs in the p53 tumor suppressor network. The exp...

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Tumor suppressor p53: regulation and function.

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P53 is a tumor suppressor gene

Arnold J. Levine, 1. Cathy A. Finlay, 2 and Philip W. Hinds 3 1Institute for Advanced Study Einstein Drive Princeton, New Jersey 08540 and Cancer Institute of New Jersey 195 Little Albany St. New Brunswick, New Jersey 08903 2 Department of High Throughput Biology GlaxoSmithKline 5 Moore Drive Research Triangle Park, North Carolina 27709 3Harvard Medical School Department of Pathology Armenise 4...

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ژورنال

عنوان ژورنال: Journal of Molecular Cell Biology

سال: 2011

ISSN: 1674-2788

DOI: 10.1093/jmcb/mjq040