Tumor suppression
نویسندگان
چکیده
منابع مشابه
Tumor suppression
The tumor suppressor gene TP53 and its gene product—a veritable swiss Army knife of cellular regulation—have been the targets of intense study since their discovery in 1979. 1-3 indeed, a PubMed search for the term " p53 " retrieves more than 68 000 citations, and more than 100 physical or genetic interactions with TP53 have been identified to date. its importance in cancer biology was recogniz...
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By and large, gene expression levels in diploid organisms reflect the combined transcription of both copies, or alleles, of that gene. Notable exceptions include genes on the X chromosome and imprinted genes. The presence of genes in only one copy or in more than two copies can have major effects on the development and fitness of an organism. Many examples of these gene dosage effects can be fo...
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Cellular senescence has emerged as a potent tumor suppression mechanism that restrains proliferation of cells at risk for malignant transformation. Although senescent cells have permanently exited the cell cycle, their presence can have detrimental effects on the surrounding tissue, largely due to the development of the senescence-associated secretory phenotype (SASP). Here, we review the tumor...
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Molecular genetic studies of familial cancer syndromes identified and defined the recessive nature of tumor suppressor genes and resolved the paradox of why tumors arising in such families exhibited an autosomally dominant pattern of inheritance. Subsequent characterization of tumor suppressor proteins revealed their widespread involvement in sporadic cancers and pinpointed key mechanisms that ...
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Cellular senescence limits the proliferative capacity of damaged cells and thereby acts as an intrinsic mechanism of tumor suppression. In this issue, Wajapeyee et al. (2008) identify insulin growth factor binding protein 7 (IGFBP7) as a secreted factor that mediates senescence induced by oncogenic BRAF in normal melanocytes. In addition, IGFBP7 triggers apoptosis in cells that have progressed ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2014
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2014.05.001