Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway
نویسندگان
چکیده
منابع مشابه
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway.
IL-23 is a proinflammatory cytokine consisting of a p19 subunit and a p40 subunit that is shared with IL-12. IL-23 is overexpressed in and around tumor tissues, where it induces local inflammation and promotes tumor development. Many tumor cells produce large amounts of lactic acid by altering their glucose metabolism. In this study, we show that lactic acid secreted by tumor cells enhances the...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2008
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.180.11.7175