Tumor progression by immune evasion in melanoma

Metamodeling tumor-immune system interaction, tumor evasion and immunotherapy

The tumor–immune system competitive interaction is very complex, being nonlinear and, to some extent, evolutive. Furthermore, the tumor itself is not a single well defined disease, but, more correctly, a wide family of diseases, characterized by some important common features, but also by many great differences between them. For this reason, we introduced in [A. d’Onofrio, A general framework f...

SPEAKERS Immune evasion by alphaherpesviruses

Immune evasion by chimeric trachea.

n engl j med 362;2 nejm.org january 14, 2010 172 erative biliary drainage for cancer of the head of the pancreas. N Engl J Med 2009;362:129-37. Chen VK, Arguedas MR, Baron TH. Expandable metal biliary 6. stents before pancreaticoduodenectomy for pancreatic cancer: a Monte-Carlo decision analysis. Clin Gastroenterol Hepatol 2005;3:1229-37. Moss AC, Morris E, MacMathuna P. Palliative biliary sten...

Molecular Markers of Tumor Progression in Melanoma

Malignant melanoma represents one of the most aggressive malignancies but outcome is highly variable with early tumor lesions having an excellent prognosis following resection. We review here the data on identification of genes involved in the progression of melanoma as a result of expression array studies, genomic profiling, and genetic models. We focus on the role of tumor suppressors involve...

Immune Evasion Mechanisms of Entamoeba histolytica: Progression to Disease

Entamoeba histolytica (Eh) is a protozoan parasite that infects 10% of the world's population and results in 100,000 deaths/year from amebic dysentery and/or liver abscess. In most cases, this extracellular parasite colonizes the colon by high affinity binding to MUC2 mucin without disease symptoms, whereas in some cases, Eh triggers an aggressive inflammatory response upon invasion of the colo...