Tumor necrosis factor inhibitors and infection complications
نویسندگان
چکیده
منابع مشابه
Tumor necrosis factor inhibitors – state of knowledge
Tumor necrosis factor (TNF) is considered a major proinflammatory cytokine, affecting various aspects of the immune reaction. All five TNF inhibitors currently available on the market (i.e., etanercept, infliximab, adalimumab, certolizumab and golimumab) are top sellers, although indicated only in autoimmune diseases, including rheumatoid arthritis, Crohn's disease and psoriasis. This article b...
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OBJECTIVE The aim of this study was to compare the levels of tumor necrosis factor-α (TNF-α) produced by peripheral blood mononuclear cells in normal pregnancies and pregnancies with complications. MATERIALS AND METHODS Maternal peripheral blood mononuclear cells from women with a recurrent spontaneous miscarriage (n = 35), premature rupture of fetal membranes (n = 30), preeclampsia (n = 27) ...
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Tumor necrosis factor (TNF) inhibitors have proven highly effective against a number of autoimmune diseases but have been disappointing in treating others. An increase in the risk of Mycobacterium tuberculosis and other opportunistic infections has been noted in patients treated with these agents. If we use these drugs, we need to weigh their beneficial and adverse effects.
متن کاملTumor necrosis factor and anti-tumor necrosis factor therapies.
Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-...
متن کاملAcute Brucella melitensis M16 infection model in mice treated with tumor necrosis factor-alpha inhibitors.
INTRODUCTION There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNFα) medication. The aim of this study was to evaluate acute Brucella infections in mice receiving anti-TNFα drug treatment. METHODOLOGY Anti-TNFα drugs were injected in mice on the first and fifth days of the study, after which the mice were ...
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ژورنال
عنوان ژورنال: Current Rheumatology Reports
سال: 2008
ISSN: 1523-3774,1534-6307
DOI: 10.1007/s11926-008-0062-1