Tumor cell‐intrinsic RIG‐I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice
نویسندگان
چکیده
Immunogenic cancer therapies, including radiation and hypomethylating agents, such as 5-azacytidine, rely on tumor cell-intrinsic activation of the RNA receptor RIG-I for their synergism with immune checkpoint inhibitors. Possible ligands are small nuclear (snRNA) endogenous retroviral elements (ERV) leaking from nucleus during programmed cell death.
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2021
ISSN: ['1521-4141', '0014-2980']
DOI: https://doi.org/10.1002/eji.202049158