Tubulin polymerization modifies cardiac sodium channel expression and gating
نویسندگان
چکیده
منابع مشابه
Tubulin polymerization modifies cardiac sodium channel expression and gating.
AIMS Treatment with the anticancer drug taxol (TXL), which polymerizes the cytoskeleton protein tubulin, may evoke cardiac arrhythmias based on reduced human cardiac sodium channel (Na(v)1.5) function. Therefore, we investigated whether enhanced tubulin polymerization by TXL affects Na(v)1.5 function and expression and whether these effects are beta1-subunit-mediated. METHODS AND RESULTS Huma...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2009
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvp352