Tuberculosis and interleukin blocking monoclonal antibodies: Is there risk?

Monoclonal Antibodies

SUMMARY Monoclonal Antibodies are identical antibodies and Can be generated in ultimated amounts by countinuos cultures of single antibody- secreting cells. These cell lines are produced by cell fusion of normal lymphocytes to cells of a myeloma tumor cell line, which confers on the antibody producing hybrid cell, immortality and the ability grow as atumor in animals. monoclonal antibodies c...

Pharmacology notes Interleukin-2 receptor-blocking monoclonal antibodies: evaluation of 2 new agents

The development of immunosuppressive agents with less toxicity and more specificity has led researchers to explore the role of interleukin-2 (IL-2) in the immunosuppression cascade. The IL-2 receptor is composed of at least 3 subunits. One subunit, the a chain, named the Tac antigen, is predominantly expressed on activated T cells. Interleukin-2 facilitates the proliferation of alloantigen-acti...

Monoclonal antibodies against chicken interleukin-6.

Monoclonal antibodies (mAb) were produced against a recombinant (r) chicken interleukin-6 (IL-6). Eight mAbs produced were tested for isotype; ability to inhibit recombinant forms of chicken (ch), human (h) and murine (m) IL-6; and recognition of rchIL-6 by Western immunoblotting. The mAb isotypes were represented by IgG1 (one), IgG2a (six) and IgG2b (one). In a mouse B9 hybridoma cell bioassay...

Monoclonal antibodies reactive with chicken interleukin-17.

Chicken interleukin-17 (chIL-17) gene was previously characterized through cloning from a chicken intestinal expressed sequence tag (EST) cDNA library. To further investigate the biological properties of chIL-17, six monoclonal antibodies (mAbs) against a bacterially expressed chIL-17 recombinant protein were produced and their binding specificities characterized. Antibodies which were initiall...

Is There a Future for Interleukin 17 Blocking Agents in Rheumatoid Arthritis?