Tryptophan-kynurenine pathway as a novel link between gut microbiota and schizophrenia: A review

Gut microbiota and its metabolite tryptophan play an important role in regulating neurotransmission, immune homeostasis oxidative stress which are critical for brain development. The kynurenine pathway is the main route of catabolism. Kynurenine metabolites regulate many biological processes including host-microbiome communication, immunity stress, as well neuronal excitability. accumulation produced by results activation system (increase levels inflammatory factors) (production reactive oxygen species, ROS), associated with mental disorders, example schizophrenia. Thus, it was hypothesized that perturbations could cause immunity, may be involved etiology present work a review latest studies on possible schizophrenia, mechanism(s) involved.