Tryptophan catabolism

Tryptophan catabolism during intracellular infection.

TO THE EDITOR—In a recent issue of the Journal, Divanovic and colleagues investigated the roles of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) during murine toxoplasmosis, cutaneous leishmaniasis, and herpes simplex virus type 1 infection [1]. They concluded from their results that IDO plays important roles in the host response and that its antimicrobial or immunoregulator...

Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion.

Tryptophan catabolism in cancer is increasingly being recognized as an important microenvironmental factor that suppresses antitumor immune responses. It has been proposed that the essential amino acid tryptophan is catabolized in the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO) expressed in tumor cells or antigen-presenting cells. This metabolic pathway creates an...

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan

Tryptophan catabolism in cancer is increasingly being recognized as an important microenvironmental factor that suppresses antitumor immune responses. It has been proposed that the essential amino acid tryptophan is catabolized in the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO) expressed in tumor cells or antigen-presenting cells. This metabolic pathway creates an...

Tryptophan catabolism and regulation of adaptive immunity.

The Role of Placental Tryptophan Catabolism

This review discusses the mechanisms and consequences of degradation of tryptophan (Trp) in the placenta, focusing mainly on the role of indoleamine 2,3-dioxygenase-1 (IDO1), one of three enzymes catalyzing the first step of the kynurenine pathway of Trp degradation. IDO1 has been implicated in regulation of feto-maternal tolerance in the mouse. Local depletion of Trp and/or the presence of met...