Trypanosoma brucei γ-Glutamylcysteine Synthetase
نویسندگان
چکیده
منابع مشابه
Characterization of ATP Binding in γ-Glutamylcysteine Synthetase
Computational and spectroscopic techniques have been combined to probe local protein structure. Experimental resonance Raman spectra were obtained for small fragments of the 29 amino acid glucose regulating protein glucagon. The Raman spectra for these fragments were also simulated computationally and were used to aid in the interpretation of the experimental spectra. Glucagon was then probed w...
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Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK Running title: Chemical Validation of Trypanothione Synthetase Address correspondence to: Julie A. Frearson, College of Life Sciences, James Black Centre, University of Dundee, Dow Street, Dundee, DD1 5EH. Tel: +44 1382 386247; Fax: +44 1382 386373; E-mail: j.a.frea...
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gamma-Glutamylcysteine synthetase is one of the enzymes of glutathione (GSH) synthesis. A deficiency of this enzyme has been found only once previously in humans: it was associated with spinocerebellar degeneration and hemolytic anemia. We report the case of a woman, daughter of fifth cousins, who was gamma-glutamylcysteine-synthetase-deficient. Modest decreases in the amount of GSH in cultured...
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In African trypanosomiasis the host-derived cytokine interferon-γ (IFN-γ) has been identified as a potent growth promoter of the causative agent Trypanosoma brucei brucei (T.b.b.). The mechanism of growth promotion involves activation of tyrosine protein kinases (TPKs). In the present study, it is shown that in contrast to the situation in multicellular eukaryotic organisms, IFN-γ-stimulated TP...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.41.26317