TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans
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TRX - 1 Regulates SKN - 1 Nuclear Localization Cell Non - Autonomously in Caenorhabditis 1 elegans 2 3
TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-Autonomously in Caenorhabditis 1 elegans 2 3 Katie C. McCallum, Bin Liu, Juan Carlos Fierro-González, Peter Swoboda, Swathi Arur, 4 Antonio Miranda-Vizuete, Danielle A. Garsin 5 6 Department of Microbiology and Molecular Genetics, The University of Texas Health Science 7 Center at Houston, Houston, Texas 77030. 8 The University of Texas Gradua...
متن کاملTRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans.
The Caenorhabditis elegans oxidative stress response transcription factor, SKN-1, is essential for the maintenance of redox homeostasis and is a functional ortholog of the Nrf family of transcription factors. The numerous levels of regulation that govern these transcription factors underscore their importance. Here, we add a thioredoxin, encoded by trx-1, to the expansive list of SKN-1 regulato...
متن کاملSKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.
The mammalian Nrf/CNC proteins (Nrf1, Nrf2, Nrf3, p45 NF-E2) perform a wide range of cellular protective and maintenance functions. The most thoroughly described of these proteins, Nrf2, is best known as a regulator of antioxidant and xenobiotic defense, but more recently has been implicated in additional functions that include proteostasis and metabolic regulation. In the nematode Caenorhabdit...
متن کاملThe thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
Dietary restriction (DR) is the only environmental intervention known to extend adult lifespan in a wide variety of animal models. However, the genetic and cellular events that mediate the anti-aging programs induced by DR remain elusive. Here, we used the nematode Caenorhabditis elegans to provide the first in vivo evidence that a thioredoxin (TRX-1) regulates adult lifespan extension induced ...
متن کاملThe Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans
The Nrf family of transcription factors plays a critical role in mediating adaptive responses to cellular stress and defends against neurodegeneration, aging, and cancer. Here, we report a novel role for the Caenorhabditis elegans Nrf homolog SKN-1 in regulating synaptic transmission at neuromuscular junctions (NMJs). Activation of SKN-1, either by acute pharmacological treatment with the mitoc...
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ژورنال
عنوان ژورنال: Genetics
سال: 2016
ISSN: 1943-2631
DOI: 10.1534/genetics.115.185272