Trip to ER

A trip to the ER

Mice lacking Muc2 had an increased ratio of proliferating to apoptotic epithelial cells, resulting in altered maturation and increased migration of epithelial cells in the intestine. They were also more likely to develop intestinal, colon, and rectal tumors. The mice are the first good model for studying rectal tumors, which are common in humans. Anticancer lubrication new mouse model for the s...

A trip to the ER: coping with stress.

The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) induces a coordinated adaptive program called the unfolded protein response (UPR). The UPR alleviates stress by upregulating protein folding and degradation pathways in the ER and inhibiting protein synthesis. With a basic conceptual framework for the UPR, including the identification of key mediators of the re...

Field trip to

I/S Nordforbrænding is an inter-municipal waste management company located north of Copenhagen, the capital of Denmark, which serves approximately 180,000 inhabitants. It was founded in 1965 and it is owned by six municipalities in North Sealand: Allerød, Søllerød, Hørsholm, Fredensborg-Humlebæk, Karlebo and Helsingør as shown in Fig. 1. The company’s mission was to establish a Waste-to-Energy ...

To trip, to slip, perchance to tumble.

A TRiP to heart failure.

Transient receptor potential (TRP) channels constitute a somewhat eclectic family of ion channels that share structural similarities and some functional properties, especially cation permeability and weak voltage sensitivity. TRP channels are expressed in virtually every cell type present in the heart, including cardiomyocytes, fibroblasts, endothelial cells and vascular smooth muscle cells. In...