TRIM32 promotes inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes
نویسندگان
چکیده
منابع مشابه
[Signal transduction of inflammatory synoviocytes in rheumatoid arthritis].
Recent advances in post-genomic technology enable us to analyze gene expression and protein modification comprehensively in tissues and cells, resulting in new developments in the analysis of molecular events of diseases. We have been studying the pathogenic and progressive mechanisms of diseases from the aspect of signalling pathways of cells. Inflammatory cytokines such as TNF-alpha and IL-1 ...
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INTRODUCTION Rheumatoid arthritis (RA) is characterized by synovial lining hyperplasia, in which there may be an imbalance between the growth and death of fibroblast-like synoviocytes (FLSs). Antibodies against citrullinated proteins are proposed to induce RA. This study aimed to investigate the pathogenic role of citrullinated fibronectin (cFn) in RA. METHODS The distribution of fibronectin ...
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Epigenetics can contribute to pathogenic mechanisms in autoimmunity, and we recently identified an imprinted DNA methylation pattern in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), involving multiple genes in pathways that have been implicated in cell migration, matrix regulation, and immune responses (1,2). To understand when alterations in DNA methylation occur in RA and the ...
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Suppression of tissue inhibitor of matrix metalloproteinase (TIMP) is associated with the tumor-like invasion of fibroblast-like synoviocytes (FLSs) that occurs during rheumatoid arthritis-related cartilage destruction. Silent information regulator 2 homolog1 (SIRT1), a histone deacetylase, is widely involved in transcriptional regulation, genomic stability, metabolism and DNA repair. Recent st...
متن کاملQuercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1.
Rheumatoid arthritis (RA) is a chronic autoimmune joint disease and fibroblast-like synoviocytes (FLS) are the resident mesenchymal cells of synovial joints. Quercetin is a dietary antioxidant. In this study, we aimed to explore the mechanisms responsible for the quercetin-induced apoptosis of FLS from patients with RA (termed RAFLS). RAFLS viability was determined following treatent of the cel...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2020
ISSN: 0300-9475,1365-3083
DOI: 10.1111/sji.12876