Trigeminal Function in Sino-Nasal Health and Disease

The upper airway (nasal passages, paranasal sinuses, pharynx, and glottis) provides the sentinel portion of human respiratory tract, with combined senses olfaction (cranial nerve I) trigeminal sensation V) signaling quality inspired air. Trigeminal function also complements sense taste (in turn mediated by cranial nerves VII, IX X), participates in genesis aversions. ability stimulation aero-digestive tract to trigger a variety behavioral reflexes has long been recognized. In this context, last three decades seen proliferation observations at molecular level regarding mechanisms olfaction, irritation, gustation. Concurrently, an ever-widening network physiological interactions between taste, uncovered. objective review is summarize relatively recent expansion research sub-field sensory science, explore clinical therapeutic implications thereof.