(Trifluoromethylselenyl)methylchalcogenyl as Emerging Fluorinated Groups: Synthesis under Photoredox Catalysis and Determination of the Lipophilicity

The synthesis of molecules bearing (trifluoromethylselenyl)methylchalcogenyl groups is described via an efficient two-step strategy based on a metal-free photoredox catalyzed decarboxylative trifluoromethylselenolation with good yields up to 88?%, which raised 98?% in flow chemistry conditions. methods allowed also scale the reaction. mechanism this key reaction was studied. physicochemical characterization these emerging performed by determining their Hansch-Leo lipophilicity parameters high values 2.24. This extended perfluoroalkylselenolation 95?%. Finally, method successfully applied functionalization relevant bioactive such as tocopherol or estrone derivatives.