Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss
نویسندگان
چکیده
منابع مشابه
Calcineurin activation contributes to noise-induced hearing loss.
Acoustic overstimulation increases Ca(2+) concentration in auditory hair cells. Because calcineurin is known to activate cell death pathways and is controlled by Ca(2+) and calmodulin, this study assessed the role of calcineurin in auditory hair cell death in guinea pigs after intense noise exposure. Immediately after noise exposure (4-kHz octave band, 120 dB, for 5 hr), a population of hair ce...
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Objective(s): Noise-induced hearing loss (NIHL) is the major cause of acquired hearing loss. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is a non- steroidal anti- inflammatory drug (NSAID) with known antioxidant and antineoplastic activity. Therefore, we monitored the extent of temporary noise- induced threshold shifts (TTS) and cochlear damage caused by high level 4- kHz noise exposure t...
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In most textbooks, it is stated that noise-induced hearing loss (NIHL) is an irreversible impairment of hearing. This is certainly true for the slowly, over time acquired NIHL. Working for years in a very noisy environment is causing a gradual killing of hair cells in the inner ear, with no hope for recovery. The other way of acquiring NIHL is by means of exposure to impact noise, and may cause...
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This paper presents noise problems associated with the use of air-turbine drills in dental practice. Two hundred and fifty dentists (male and female) were randomly selected from the faculty of dentistry as well as the dentists who worked private in Tehran. The results indicated that the mean value of sound pressure level produced by the high-speed drills was 69.1 db. Most of the energy from...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2021
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.648461