منابع مشابه
Genetics of vascular calcification.
Recessive mutations in the NTE5 gene were recently described in lower-extremity vascular calcification. ENPP1 mutations were previously described in a severe disorder of vascular calcification in infancy. Together these data support that extracellular adenosine and pyrophosphate are essential components of the pathways in vascular disease. Arterial calcification by impairing blood flow and redu...
متن کاملMechanism of vascular calcification
In the early 1900s, cholesterol deposition in atherosclerosis was considered a passive, degenerative, inevitable and end-stage process of ageing. After decades of research, it is now recognized as an active, regulated, treatable and preventable disorder related to deposition and oxidation of lipoprotein components. Similarly, in the past few decades, vascular calcification also has been conside...
متن کاملInflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells
The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...
متن کاملEstrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification.
RATIONALE Arterial calcification and osteoporosis are associated in postmenopausal women. RANK (the receptor activator of nuclear factor kappaB), RANKL (RANK ligand), and osteoprotegerin are key proteins in bone metabolism and have been found at the site of aortic calcification. The role of these proteins in vasculature, as well as the contribution of estrogen to vascular calcification, is poor...
متن کامل[Vascular calcification in CKD].
As doenças cardiovasculares (DCV) constituem a principal causa de mortalidade em pacientes com doença renal crônica (DRC).1 O risco de óbito por DCV nessa população chega a ser 10 a 30 vezes maior que aquele observado na população geral. Esse aumento da mortalidade também ocorre em pacientes nos estágios precoces da DRC,2 assim como naqueles submetidos a transplante renal.3 A alta prevalência d...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2008
ISSN: 0085-2538
DOI: 10.1038/ki.2008.502