Treatment of subepidermal immunobullous diseases

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Immunofluorescence in Oral Pathology—Part II: Pathology and Immunofluorescent Patterns in Subepidermal Immunobullous Disorders

The immunobullous disorders are a group of autoimmune diseases in which components of the epidermis and basement membrane zone are targeted, resulting in the formation of cutaneous and mucosal blisters. Based on the level of blistering, the autoimmune blistering diseases may be subdivided into intraepidermal and subepidermal. An exhaustive list of immunobullous disorders is beyond the scope of ...

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Antiplectin autoantibodies in subepidermal blistering diseases.

BACKGROUND Hemidesmosomal proteins may become targets of autoimmunity in subepidermal blistering diseases. Well-known recognized autoantigens are the intracellular plaque protein BP230, the transmembrane BP180 and its shed ectodomain LAD-1. OBJECTIVES To establish the prevalence of autoimmunity against plectin, another intracellular plaque protein, and to investigate its antigenic sites. ME...

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A subepidermal blistering disorder.

A young woman presented with generalised tense blisters. There had been no previous drug exposure and she had no clinical signs of autoimmune disease or evidence of sepsis. Given the abrupt onset and clinical scenario, a skin punch biopsy was performed and a tentative diagnosis of linear IgA bullous dermatosis (LABD) was made. Dapsone, an immunomodulatory sulfone that has been supported for use...

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ژورنال

عنوان ژورنال: Clinics in Dermatology

سال: 2012

ISSN: 0738-081X

DOI: 10.1016/j.clindermatol.2011.03.015