Treatment of lymphoblastic leukemia in children with Down syndrome

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Acute leukemia in children with Down syndrome

Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA. Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI, USA. Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA. Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. E-mail: [email protected]. doi:10.33...

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Background and Objective: Tumor lysis syndrome (TLS) could occur before, during or after the initiation of chemotherapy in patients with cancers especially those with hematologic malignancies. This study was designed to determine the prevalence and predictors of TLS in children with Acute Lymphoblastic Lymphoma (ALL) and to develop a sensitive prediction rule to identify patients at low risk of...

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Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.

We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received myeloablative conditioning and 52% underwent transplantation in second remission. Disease-free survival (DFS) was 24% at a median of 3 years. Post-transplant leukemic relapse was...

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UBE2Q1, as Down Regulated Gene in Pediatric Acute Lymphoblastic Leukemia

Ubiquitin - proteasome system (UPS), the major protein degradation pathway in the cells, typically degrades short - lived and damaged proteins and regulates growth and stress responses. This pathway is altered in various cancers, including Acute Lymphoblastic Leukemia (ALL). ALL begins with a change in bone marrow cells and is the most common type of leukemia in children under 15 years. UBE2Q1...

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ژورنال

عنوان ژورنال: Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)

سال: 2021

ISSN: 2500-2228,1027-4065

DOI: 10.21508/1027-4065-2021-66-2-105-109