Treatment of human African trypanosomiasis—present situation and needs for research and development

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Treatment of human African trypanosomiasis--present situation and needs for research and development.

Human African trypanosomiasis re-emerged in the 1980s. However, little progress has been made in the treatment of this disease over the past decades. The first-line treatment for second-stage cases is melarsoprol, a toxic drug in use since 1949. High therapeutic failure rates have been reported recently in several foci. The alternative, eflornithine, is better tolerated but difficult to adminis...

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ژورنال

عنوان ژورنال: The Lancet Infectious Diseases

سال: 2002

ISSN: 1473-3099

DOI: 10.1016/s1473-3099(02)00321-3