Treatment of Gonorrhoea with P.A.M. and Probenecid

PAM plus probenecid and procaine penicillin plus probenecid in gonorrhoea.

In 1944, when gonorrhoea responded to 100,000 units of crystalline penicillin given in divided doses, Miller, Scott, and Moeller (1944) observed that the gonococcus was cleared from the urethral secretions within 1 to 6 hours. 23 years later, Holmes, Johnson, and Floyd (1967), in the Far East, noted that only one case, a therapeutic failure, out of twenty treated with 2-4 m.u. procaine penicill...

Treatment of gonorrhoea with procaine penicillin plus probenecid.

Ampicillin plus probenecid compared with procaine penicillin plus probenecid in the treatment of gonorrhoea.

396 male patients with gonococcal urethritis were treated by one of three treatment schedules. Of 132 patients treated with 2.4 m.u. procaine penicillin plus 2 g. probenecid, 109 were followed. There were three (2.8 per cent) recurrences in the first week and none in the second. Of 132 patients treated with 2 g. ampicillin plus 2 g. probenecid, 112 were followed. There were four (3.6 per cent.)...

Treatment of gonorrhoea in Singapore using penicillin plus probenecid.

Wilcox (1970), in reviewing the problems of treating gonorrhoea in South-East Asia, noted that relatively large doses of penicillin had been used in the region for the last 10 years, but that nevertheless failure rates of 30 per cent. and higher had often been reported. When treating gonorrhoea acquired in the Philippines and Hong Kong, Holmes, Johnson, and Floyd (1967a) found that treatment wi...

Pivampicillin HCl-probenecid combination in the treatment of uncomplicated gonorrhoea.

A new semisynthetic oral penicillin, pivampicillin HCG, is rapidly hydrolysed to ampicillin in the body. Because of efficient absorption from the gastrointestinal tract, it is reported to give serum concentrations considerably higher than those obtained with a corresponding dose of ampicillin (Frederiksen, Godtfredsen, Nielsen, and Roholt, 1971). A previous study (F6rstrom and Lassus, 1972) sho...