Treatment of experimental disseminated candidiasis with cilofungin
نویسندگان
چکیده
منابع مشابه
Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits.
Cilofungin has potent in vitro activity against Candida albicans, but previous in vivo models using twice daily intermittent dosing regimens have not consistently demonstrated in vivo efficacy. Because of the pharmacokinetics of cilofungin in rabbits, it has been suggested that administration by continuous intravenous infusion might be more effective. We compared the in vivo efficacy of continu...
متن کاملTreatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304.
We studied the pharmacokinetics and in vivo antifungal action of SCH39304, a new antifungal azole compound, in rabbits. It crossed the blood-cerebrospinal fluid barrier in the presence or absence of meningeal inflammation, reaching approximately 60% of the simultaneous concentrations in serum. In the treatment of experimental cryptococcal meningitis, SCH39304 was as effective as fluconazole in ...
متن کاملMycological and histopathological findings of experimental disseminated candidiasis in dogs
Disseminated candidiasis is an opportunistic infection in immunosuppressed animals by Candida species. The purposes of this study were to determine the predominant candidal forms in different tissues and tissue reactions. Sixteen dogs were selected in this study. The treatment dogs were immunosuppressed by intravenous administration of cyclophosphamide and after 5 days, they were challenged wit...
متن کاملIn vitro lymphoproliferative response and cytokine production in mice with experimental disseminated candidiasis
Objective(s): Systemic candidiasis is an infection of Candida albicans (C. albicans) causing disseminated disease and sepsis, invariably when host defenses are compromised. We investigated the histopathological changes as well as the lymphoproliferative responses and cytokine production of splenic cells after stimulation with Concanavalin A (Con A) and Pokeweed mitogen (PWM) in mice with dissem...
متن کاملTreatment of murine disseminated candidiasis with L-743,872.
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1989
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.33.10.1811