Treatment-Emergent Influenza Virus Polymerase Acidic Substitutions Independent of Those at I38 Associated With Reduced Baloxavir Susceptibility and Virus Rebound in Trials of Baloxavir Marboxil
نویسندگان
چکیده
منابع مشابه
Influenza virus nucleoprotein interacts with influenza virus polymerase proteins.
Influenza virus nucleoprotein (NP) is a critical factor in the viral infectious cycle in switching influenza virus RNA synthesis from transcription mode to replication mode. In this study, we investigated the interaction of NP with the viral polymerase protein complex. Using coimmunoprecipitation with monospecific or monoclonal antibodies, we observed that NP interacted with the RNP-free polyme...
متن کاملMortality of wild swans associated with naturally infection with highly pathogenic H5N1 avian influenza virus in Iran
In the February 2006 in two wetlands in northern Iran, the mortality among wild swans was observed. Paralysis was the most prominent feature of the disease. Histologically, diffused necrosis of acinar cells in pancreas, degeneration and necrosis of some neurons in central nervous system (CNS), sever necrotic and hemorrhagic enteritis, foci of haemorrahge and myocardial cell necrosis in the he...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2020
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiaa164