Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors
نویسندگان
چکیده
منابع مشابه
Urinary tract infection: diagnosis, treatment and prevention.
Healthcare interventions can be episodic, and a target-based culture can lead to clinicians focusing on treating and discharging a person in a certain time frame to meet targets. When health care is delivered in pressurized acute environments, a holistic approach to a person's health may be lost. Urinary tract infection is the most common healthcare-acquired infection in the UK, and treatment i...
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Chaperone-usher pathway pili are a widespread family of extracellular, Gram-negative bacterial fibers with important roles in bacterial pathogenesis. Type 1 pili are important virulence factors in uropathogenic Escherichia coli (UPEC), which cause the majority of urinary tract infections (UTI). FimH, the type 1 adhesin, binds mannosylated glycoproteins on the surface of human and murine bladder...
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Background: Bacteremia is relatively common in children with urinary tract infection (UTI). The aim of the present study was to determine the frequency of bacterial meningitis among neonates with laboratory-confirmed UTI.Methods: This retrospective cross-sectional study was performed on 163 hospitalized neonates in Ali Asghar and Shahid Akbarabadi hospitals affiliated to Iran University o...
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Lower urinary tract infections are very common diseases. Recurrent urinary tract infections remain challenging to treat because the main treatment option is long-term antibiotic prophylaxis; however, this poses a risk for the emergence of bacterial resistance. Some options to avoid this risk are available, including the use of cranberry products. This article reviews the key methods in using cr...
متن کاملPrevention of catheter-associated urinary tract infection.
PURPOSE OF REVIEW The underlying cause of catheter-associated urinary tract infection is biofilm formation by uropathogens on the urinary catheter. Biofilm is a relatively new concept in medicine, and current measures to prevent biofilm formation are inadequate. Considerable work is being done in this area, but little clinical progress has been made. The purpose of this review is to analyze rec...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2011
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.3003021