منابع مشابه
Transporting mitochondria in neurons
Neurons demand vast and vacillating supplies of energy. As the key contributors of this energy, as well as primary pools of calcium and signaling molecules, mitochondria must be where the neuron needs them, when the neuron needs them. The unique architecture and length of neurons, however, make them a complex system for mitochondria to navigate. To add to this difficulty, mitochondria are synth...
متن کاملThe effect of adenosine triphosphate on the tricarboxylate transporting system of rat liver mitochondria.
ATP has two significant effects on the mitochondrial tricarboxylate transporting system. First, it alters the concentration gradients at equilibrium for the substrates of this transporter. ATP (2MM) caused the uptake of 10 nmol of citrate into the mitochondria coincident with the output of a similar amount of L-malate. This redistribution was dependent on ATP transport, the effect being inhibit...
متن کاملMitochondria in the life and death of neurons.
A prolonged decrease in ATP levels underlies a number of neurodegenerative disorders. Defects in oxidative phosphorylation are associated with a number of neurodegenerative disorders. Mitochondria also play an important role in mediating the initiation of apoptosis.
متن کاملExtensive Fusion of Mitochondria in Spinal Cord Motor Neurons
The relative roles played by trafficking, fission and fusion in the dynamics of mitochondria in neurons have not been fully elucidated. In the present study, a slow widespread redistribution of mitochondria within cultured spinal cord motor neurons was observed as a result of extensive organelle fusion. Mitochondria were labeled with a photoconvertible fluorescent protein (mitoKaede) that is re...
متن کاملAn employee transporting problem
An employee transporting problem is described and a set partitioning model is developed. An investigation of the model leads to a knapsack problem as a surrogate problem. Finding a partition corresponding to the knapsack problem provides a solution to the problem. An exact algorithm is proposed to obtain a partition (subset-vehicle combination) corresponding to the knapsack solution. It require...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2016
ISSN: 2046-1402
DOI: 10.12688/f1000research.7864.1