Transport of Adenine-8-C14 among Mouse Tissues by Blood Cells
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چکیده
منابع مشابه
A comparison of the oxidation of octanoate-1-C14, -7-C14, and butyrate-1-C14 by neoplastic and normal mouse tissues.
The degradation of fatty acids of the even series by animal tissues yields Ca fragments (metabolically, acetyl-S-CoA) which may undergo various condensation reactions. Condensation with oxalacetate to form citrate is the established mecha nism for entrance of €2fragments into the tricarboxylic acid cycle, where they are subsequently oxidized to COs (11, 17). Liver possesses the abil ity to fo...
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Brown and associates (2, 9) conclusively demon strated that isotopically labeled adenine was in corporated into the purines of the nucleic acids of normal tissues. The results of these and other in vestigators indicated that the uptake of the labeled compound into the cytoplasmic ribonucleic acid (RNA) was considerably greater than that into the desoxyribonucleic acid (DNA). In re generating li...
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A biochemical investigation (1, 2) of the incorporation of adenine-8-C '4 and orotic-6-C 14 acid into the nucleic acids of the adult feline neuraxis showed rapid uptake of these precursors into pentosenucleic acid (PNA) in both white and gray matter. Deoxypentosenucleic acid (DNA) exhibited little, if any, uptake in short term experiments. In chronic experiments, however, the D N A fraction acq...
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nine labeled either with C'4 or N'5. Considerable controversy has developed as to which one of these tracer compounds gives an accurate measurement of the “relativeturnover-rate― of the nucleic acids. In order to determine the “absolute turnover rate― of the nucleic acids, it is necessary to know the specific activity of the immediate precursor of the nucleic acids. Since even the ident...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69652-8