Transplacental influence of the thymus.

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Transplacental influence of the thymus

Peripheral blood lymphocyte levels attained in adult rats that had been thymectomized at birth were markedly reduced if the two or three immediately preceding generations of rats from which they were bred had been thymectomized as neonates. The capacity of thymectomized animals to survive to adult life was also drastically reduced if they were bred from thymectomized stock. Pregnancy as a resul...

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Brief Definitive Report Transplacental Influence of the Thymus

This report presents evidence for the proposition that the thymus is able to influence the recirculating lymphocyte population in ways other than through the provision of cells. The operation of humoral mechanisms, initiated by the thymus, is inferred from the demonstration that changes in lymphocyte levels consequent upon thymectomy are shown to operate across the placenta. Following the obser...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1977

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.145.3.772