Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay
نویسندگان
چکیده
منابع مشابه
Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein
Chronic wasting disease (CWD) is a prion disease that affects free-ranging and captive cervids, including mule deer, white-tailed deer, Rocky Mountain elk and moose. CWD-infected cervids have been reported in 14 USA states, two Canadian provinces and in South Korea. The possibility of a zoonotic transmission of CWD prions via diet is of particular concern in North America where hunting of cervi...
متن کاملAtypical Scrapie Prions from Sheep and Lack of Disease in Transgenic Mice Overexpressing Human Prion Protein
Public and animal health controls to limit human exposure to animal prions are focused on bovine spongiform encephalopathy (BSE), but other prion strains in ruminants may also have zoonotic potential. One example is atypical/Nor98 scrapie, which evaded statutory diagnostic methods worldwide until the early 2000s. To investigate whether sheep infected with scrapie prions could be another source ...
متن کاملHuman prion protein sequence elements impede cross-species chronic wasting disease transmission.
Chronic wasting disease (CWD) is a fatal prion disease of North American deer and elk and poses an unclear risk for transmission to humans. Human exposure to CWD occurs through hunting activities and consumption of venison from prion-infected animals. Although the amino acid residues of the prion protein (PrP) that prevent or permit human CWD infection are unknown, NMR-based structural studies ...
متن کاملResistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein.
Prion protein (PrP) is a required factor for susceptibility to transmissible spongiform encephalopathy or prion diseases. In transgenic mice, expression of prion protein (PrP) from another species often confers susceptibility to prion disease from that donor species. For example, expression of deer or elk PrP in transgenic mice has induced susceptibility to chronic wasting disease (CWD), the pr...
متن کاملTransmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains.
In vitro screening using the cell-free prion protein conversion system indicated that certain rodents may be susceptible to chronic wasting disease (CWD). Therefore, CWD isolates from mule deer, white-tailed deer, and elk were inoculated intracerebrally into various rodent species to assess the rodents' susceptibility and to develop new rodent models of CWD. The species inoculated were Syrian g...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2019
ISSN: 1297-9716
DOI: 10.1186/s13567-019-0626-2