منابع مشابه
Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics
Rhomboid proteases reside within cellular membranes, but the advantage of this unusual environment is unclear. We discovered membrane immersion allows substrates to be identified in a fundamentally-different way, based initially upon exposing 'masked' conformational dynamics of transmembrane segments rather than sequence-specific binding. EPR and CD spectroscopy revealed that the membrane restr...
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ژورنال
عنوان ژورنال: Protoplasma
سال: 1999
ISSN: 0033-183X,1615-6102
DOI: 10.1007/bf01282993