Transmembrane 29 (Tmem29), a Newly Identified Molecule Showed Downregulation in Hypoxic-Ischemic Brain Damage

Transmembrane 29 (Tmem29) gene with unknown function is a located on the X chromosome of mouse genome. The showed differential expression in Vannucci neonatal hypoxic-ischemic brain model. We found expresses different molecular forms, including group long non-coding RNA forming family transcripts. It was predominantly expressed testes, brain, and kidney mouse. In vitro identification functional characterization were carried out Neuro2a cells. Using fluorescence microscopy, Tmem29 protein to be constitutively cell lines origins. Oxygen glucose deprivation (OGD) induced apoptotic death cells confirmed by activations caspase 3. associated especially at time points 3 activations. A similar response obtained (GD) cultures suggesting common mechanism OGD GD. Downregulation GD, further validating its hypoxia-ischemia (HI) insults. Our findings contributed understanding events after insults opens new avenues for developing protective therapeutic strategies encephalopathy or even pathological programmed death.