Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Continuous Granulation with a Twin-Screw Extruder

Preparation of solid dispersion for ethenzamide-carbopol and theophylline-carbopol systems using a twin screw extruder.

In the present study, we prepared solid dispersions of water-insoluble and soluble drugs (ethenzamide (ETZ) and theophylline (THEO)) by the twin screw extruder method, which made it possible to control both kneading and heating at the same time under the fusion point of each drug, using three types of the controlled-release high-molecular-weight substance Carbopol (CAR) as the carrier. The soli...

Wet granulation in a twin-screw extruder: implications of screw design.

Wet granulation in twin-screw extrusion machinery is an attractive technology for the continuous processing of pharmaceuticals. The performance of this machinery is integrally tied to its screw design yet little fundamental knowledge exists in this emerging field for granulation to intelligently create, troubleshoot, and scale-up such processes. This study endeavored to systematically examine t...

Aqueous extraction of residual oil from sunflower press cake using a twin-screw extruder: Feasibility study

The objective of this study was to evaluate the feasibility of an aqueous process to extract the residual oil from sunflower press cakes using a co-rotating twin-screw extruder. Two different configurations were tested: the expression fromwhole seeds followed by the aqueous extraction, in two successive apparatus or in the same one. For the aqueous extraction stage, the oil yield depended on th...

Modeling Residence Time Distribution in a Twin-Screw Extruder as a Series of Ideal Steady-State Flow Reactors

Knowledge about and control of residence time distribution (RTD) is critical for determining optimal conditions in an extrusion process. In this paper, previously proposed models for RTD have been summarized and compared with the experimental data. The best-fit model was found to be a plug flow in series with a finite number of constantly stirred tank reactors having dead volume fractions. Para...