Transient monoarthritis and psoriatic skin lesions following COVID-19

Evaluation of COVID-19 incidence in psoriatic patients receiving Adalimumab

Background: Adalimumab is a highly human monoclonal antibody that binds to tumor necrosis factor, a key proinflammatory cytokine pathogenic in psoriasis. It considers an influential factor in controlling moderate to severe psoriasis. This study aimed to evaluate the impact of Adalimumab on COVID-19 incidence in patients with psoriasis. Methods: This cross-sectional study was performed at Baqiy...

Psoriatic skin lesions induced by tumor-necrosis-factor-alpha-therapy

A 46-year-old, caucasian woman suffering from Crohn’s disease and a 35-year-old woman suffering from ankylosing spondylitis were treated with the TNFα blocker infliximab and developed psoriasiform skin lesions. The pathophysiology of this paradoxical clinical response as a newly recognized adverse effect of TNFα antagonists is unknown. According to the literature, this type of newly triggered p...

Skin Lesions: Enhanced Expression in Psoriatic Keratinocytes in Healthy Skin and Psoriasis

COVID-19 and dermatologists

Since the beginning of COVID-19 pandemic on December 2019, challenges on economic, political, social, hygiene- therapeutic and life style have emerged in many countries. Many researches are investigating on virus characteristics and its behavior and also preventive and therapeutic measures. Despite the virus not being dermatotropic, several skin manifestations have been observed. In this review...

Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment

Psoriasis is a type I interferon-driven T cell-mediated disease characterized by the recruitment of plasmacytoid dendritic cells (pDC) into the skin. The molecules involved in pDC accumulation in psoriasis lesions are unknown. Chemerin is the only inflammatory chemotactic factor that is directly active on human blood pDC in vitro. The aim of this study was to evaluate the role of the chemerin/C...