Transient Exposure of Rhesus Macaque Oocytes to Calyculin-A and Okadaic Acid Stimulates Germinal Vesicle Breakdown Permitting Subsequent Development and Fertilization1
نویسندگان
چکیده
منابع مشابه
Biology of Reproduction
Exposure of mammalian oocytes to the protein phosphatase (PP)-1 (PP1) and PP2A inhibitor okadaic acid (OA) stimulates oocyte meiosis. However, treated oocytes do not develop beyond metaphase I (MI), and they display morphological aberrations. Experiments were conducted to define inhibitor treatment conditions for macaque oocytes that would result in germinal vesicle breakdown (GVB) stimulation ...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1998
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod58.4.880