Transient Convection, Diffusion, and Adsorption in Surface-Based Biosensors

Transient convection, diffusion, and adsorption in surface-based biosensors.

This paper presents a theoretical and computational investigation of convection, diffusion, and adsorption in surface-based biosensors. In particular, we study the transport dynamics in a model geometry of a surface plasmon resonance (SPR) sensor. The work, however, is equally relevant for other microfluidic surface-based biosensors, operating under flow conditions. A widely adopted approximate...

Nanobiosensors and fluorescence based biosensors: An overview

A biosensor can sense biological elements after interaction with the recognition element. The signal produced due to interaction of the analyte with its biochemical element is transduced by a transducer and detected by appropriate modes. The miniaturization of these biosensors at the nano level using nanostructures as a platform for sensing the analyte or its detection is called a nanobiosensor...

Adsorption-induced conformational changes in protein diffusion-aggregation surface assemblies.

Two-dimensional rigid colloid aggregation models may be applied to protein layers when no large conformational change is involved. Yet, following adsorption, several proteins undergo a conformational transition that may be involved in aggregative structures. Our focus here is how a conformational change might influence surface clustering in a diffusion-aggregation model. We propose a model incl...

Graphene Oxide Based Surface Plasmon Resonance Biosensors

Graphene oxide (GO), an amorphous insulatormaterial, has consists of a hexagonal ring based carbon network having both sp2-hybridized carbon atoms and sp3-hybridizedcarbons bearing hydroxyl andepoxide functional groups on either side of the sheet, whereas the sheet edges are mostly decorated by carboxyl and carbonyl groups [1-6]. These unique properties hold great promise for potential applicat...

Adsorption in Extracorporeal Blood Purification: How to Enhance Solutes Removal Beyond Diffusion and Convection