Transglutaminases Are Active in Perivascular Adipose Tissue

Perivascular adipose tissue contains functional catecholamines

The sympathetic nervous system and its neurotransmitter effectors are undeniably important to blood pressure control. We made the novel discovery that perivascular adipose tissue (PVAT) contains significant concentrations of catecholamines. We hypothesized that PVAT contains sufficient releasable catecholamines to affect vascular function. HPLC, isometric contractility, immunohistochemistry, wh...

Perivascular adipose tissue, vascular reactivity and hypertension.

Most blood vessels are surrounded by a variable amount of adventitial adipose tissue, perivascular adipose tissue (PVAT), which was originally thought to provide mechanical support for the vessel. It is now known that PVAT secretes a number of bioactive substances including vascular endothelial growth factor, tumor necrosis factor-alpha (TNF-α), leptin, adiponectin, insulin-like growth factor, ...

Perivascular adipose tissue and coronary vascular disease.

Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct phenotype relative to other adipose depots and is capa...

Insulin-Induced Changes in Skeletal Muscle Microvascular Perfusion are Regulated by Perivascular Adipose Tissue in Women

Rationale Obesity increases the risk of cardiovascular disease and type 2 diabetes, at least partly through its association with microvascular dysfunction and insulin resistance. In the skeletal muscle microcirculation of obese subjects, insulin’s vasodilator effects are impaired, reducing insulin-induced glucose delivery and uptake. Here, we studied whether perivascular adipose tissue (PVAT) c...

Accuracy and Artistry in Anatomical Illustration of Perivascular Adipose Tissue