Transgenic plants for animal health: plant-made vaccine antigens for animal infectious disease control

Plant-made vaccine antigens and biopharmaceuticals.

Plant cells are ideal bioreactors for the production and oral delivery of vaccines and biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold storage, transportation and sterile delivery. Plant-made vaccines have been developed for two decades but none has advanced beyond Phase I. However, two plant-made biopharmaceuticals are now advancing through Phase II and ...

Small Animal - Infectious Disease

INTRODUCTION Historically, studies from our research group have involved intracellular pathogens in the Genera Babesia, Ehrlichia, Rickettsia, and more recently, Bartonella. In regard to the study of these obligate intracellular or in the case of Bartonella sp., highly fastidious pathogens, clinical, as well as more basic research initiatives, have been hampered by difficulties associated with ...

Humane endpoints for infectious disease animal models.

Since the work of pioneers such as Jenner and Pasteur (Fenner et al. 1997) more than a century ago, animal models have provided essential information in the study of infectious diseases. Although much experimentation can now be accomplished with in vitro systems, animals continue to be necessary for this field for studying the process of inflammation, specific infectious diseases, and pharmacol...

Plant-based vaccines for animal health.

Plant-based vaccines are recombinant protein subunit vaccines. Ideally, the choice of plant species used to produce the selected antigen should allow for oral delivery in the form of an edible vaccine. These vaccines are well suited to combat diseases where there is a clear antigen candidate, and where the costs of production or delivery for any current vaccine are prohibitive. Several academic...

Efficacy of Experimental Inactivated Vaccine for Infectious Bronchitis Disease