Transgenic Models In Endocrinology

Fish and Amphibian Models for Developmental Endocrinology

The hormonal control of ontogeny in fish and amphibians is reviewed. Neuroendo. crine regulation and actions of metabolic and osmoregulatory hormones (thyroid, interrenal, pituitary, pancreas, and gut) during amphibian and fish metamorphosis and the parr-smolt transformation of juvenile salmon are considered. The developmental significance of hormones in egg yolk is discussed. It is concluded t...

Integrated Endocrinology Integrated Endocrinology

Transgenic Models in Retinoblastoma Research.

Understanding the mechanism of retinoblastoma (Rb) tumor initiation, development, progression and metastasis in vivo mandates the use of animal models that mimic this intraocular tumor in its genetic, anatomic, histologic and ultrastructural features. An early setback for developing mouse Rb models was that Rb mutations did not cause tumorigenesis in murine retinas. Subsequently, the discovery ...

Carcinogenesis in transgenic mouse models.

Background: Safe and effective weight control strategies are needed to stem the current obesity epidemic. The objective of this one-year study was to document and compare the macronutrient and micronutrient levels in the foods chosen by women following two different weight reduction interventions. Methods: Ninety-six generally healthy overweight or obese women (ages 25–50 years; BMI 25– 35 kg/m...

The Transgenic Animal Models

Shortly after discovery of ET-1 in 1988, the entire endothelin system was characterized. The endothelin system consists of the three peptides ET-1, ET-2 and ET-3, their G-protein-coupled receptors endothelin receptor A and B (ETRA and ETRB) and the two endothelin-converting enzymes (ECE-1 and ECE-2). Genetically modified animal models are an important tool in biomedical research. Here we descri...