Transfusion immunomodulation — the case for leukoreduced and (perhaps) washed transfusions
نویسندگان
چکیده
منابع مشابه
A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia [ISRCTN76536440]
BACKGROUND: Platelet transfusion is universally employed in acute leukemia. Platelet concentrate supernatants contain high concentrations of biologic mediators that might impair immunity. We investigated whether washed platelet and red cell transfusions could improve clinical outcomes in adult patients with acute leukemia. METHODS: A pilot randomized trial of washed, leukoreduced ABO identical ...
متن کاملPrevention of transfusion-transmitted cytomegalovirus in low-birth weight infants (≤1500 g) using cytomegalovirus-seronegative and leukoreduced transfusions.
The transfusion-transmitted cytomegalovirus (TT-CMV) can cause serious morbidity and mortality in low-birth weight infants (LBWIs). Transfusion-transmitted cytomegalovirus can be minimized in LBWIs born to cytomegalovirus (CMV)-seronegative mothers with the use of CMV-seronegative blood components. Despite evidence that has independently shown that either leukoreduction or the use of CMV-serone...
متن کاملTransfusion Medicine 2 Platelet transfusions
Ever since platelet transfusions were shown to reduce mortality from haemorrhage in patients with acute leukaemia in the 1950s, the use of this therapy has steadily grown to become an essential part of the treatment of cancer, haematological malignancies, marrow failure, and haematopoietic stem cell transplantation. Today, more than 1·5 million platelet products are transfused in the USA each y...
متن کاملTransfusion reactions to plasma constituent of whole blood; their pathogenesis and treatment by washed red blood cell transfusions.
EACTIONS to the transfusion of blood are ordinarily classified as pyrogenic, allergic or hemolytic. The first two are relatively minor in importance, but hemolytic transfusion reactions, usually due to the use of incompatible blood, are severe and may be lethal. Another type of reaction to whole blood, not previously described, was observed by us in at least ii cases during the past three years...
متن کاملPost-transfusion purpura and multiple transfusions.
Post-transfusion thrombocytopenic purpura (PTTP) is an acute, severe, and transient condition occurring in patients about one week after transfusion, presumably owing to a common soluble platelet antigen in the donor blood that stimulates formation of a complement-fixing isoantibody in the recipient. Antigen-antibody complexes are formed and become fixed to recipient platelets, which are then p...
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ژورنال
عنوان ژورنال: Blood Cells, Molecules, and Diseases
سال: 2013
ISSN: 1079-9796
DOI: 10.1016/j.bcmd.2012.08.009