Transforming growth factor β as a possible independent factor in chronic hepatitis B

To investigate the association between immune-cell-related cytokines and development of chronic hepatitis B (CHB), patients with virus (HBV) infection in immunotolerant (IT) phase (n = 30) or envelope antigen (HBeAg)-positive CHB 250) were enrolled this study. Serological indicators plasma cytokine levels measured at time enrollment. The results showed that there significant differences median age (27 vs. 31 years), alanine aminotransferase (ALT, 29.85 234.70 U/L), (AST, 23.40 114.90 HBsAg (4.79 3.88 log10 IU/ml), HBeAg (1606.36 862.47 S/CO), HBV DNA load (8.17 6.71 IU/ml) IT groups (all P < 0.01). values Fms-like tyrosine kinase 3 ligand (FLT3-L), interferon-gamma (IFN-γ), interleukin- 17A (IL-17A), transforming growth factor beta (TGF-β1) significantly higher group than (FLT3-L, 41.62 27.47 pg/ml; IFN-γ, 42.48 33.18 IL-17A, 15.66 8.90 TGF-β1, 4921.50 2234 all IFN-α2, TGF-β3 IL-10 lower those (IFN-α2, 15.24 35.78 pg/ml, 0.000; TGF-β3, 131.69 162.61 0.025; IL-10, 5.02 7.9 0.012). Multivariate logistic regression analysis indicated TGF-β 1 (OR 0.999, 95% CI 0.999-1.000, 0.001) TGF-β2 1.008, 95%CI 1.004-1.012, modestly but associated incidence CHB. suggest level might be an independent related to occurrence