Transformation of chronic lymphocytic leukemia into B-cell acute lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Rapid transformation of chronic lymphocytic leukemia to acute lymphoblastic leukemia: A rare case report.
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature-appearing lymphocytes in blood, bone marrow, lymph nodes, and spleen with a median lymphocyte count of 20-30 × 10(9)/L at the time of diagnosis. In half of the patients, the lymphocyte count doubles over a period of 1-year and cyclic rise up to 50 × 10(9)/L can occur in untreated patients while in others the count...
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Transformation of chronic lymphocytic leukemia to acute lymphoblastic leukemia is extremely rare. We describe an elderly patient whose lymphocytes on presentation were morphologically characteristic of chronic lymphocytic leukemia, but changed to lymphoblasts in a very short interval. Peripheral blood mononuclear cells were tested for surface immunoglobulins and T65 antigen at initial presentat...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2017-11-819276