Transdermal diffusion of resveratrol by multilamellar liposomes: Effect of encapsulation on its stability

Trans-Resveratrol (RV) was encapsulated in multi-lamellar liposomes (MLLs) composed of a mixture phosphatidylcholine (P100), Tween 80 (T80) and water. The P100-to-T80 ratio as well their water content were chosen based on previous study to promote transdermal transport RV. effect RV the size, elasticity, charge MLLs evaluated encapsulation apparent solubility diffusion artificial skin, namely Strat-M™, monitored by confocal Raman imaging, compared with that solution empty MLLs, while passage rate measured UV–vis spectrophotometry both excised human skin. found remain localized outer layer skin less than 3% passing through it over 24-h period types. Encapsulation drastically increased its passage: 73 ± 10% after 3 h incubation Strat-M™ 9 h. Whereas free form underwent cis isomerization, protected up 9h before undergoing chemical degradation 24h.