Transdermal deferoxamine prevents pressure-induced diabetic ulcers
نویسندگان
چکیده
منابع مشابه
Transdermal deferoxamine prevents pressure-induced diabetic ulcers.
There is a high mortality in patients with diabetes and severe pressure ulcers. For example, chronic pressure sores of the heels often lead to limb loss in diabetic patients. A major factor underlying this is reduced neovascularization caused by impaired activity of the transcription factor hypoxia inducible factor-1 alpha (HIF-1α). In diabetes, HIF-1α function is compromised by a high glucose-...
متن کاملCandesartan restores pressure-induced vasodilation and prevents skin pressure ulcer formation in diabetic mice
BACKGROUND Angiotensin II type 1 receptor (AT1R) blockers have beneficial effects on neurovascular complications in diabetes and in organ's protection against ischemic episodes. The present study examines whether the AT1R blocker candesartan (1) has a beneficial effect on diabetes-induced alteration of pressure-induced vasodilation (PIV, a cutaneous physiological neurovascular mechanism which c...
متن کاملHealing of elderly patients with diabetic foot ulcers, venous stasis ulcers, and pressure ulcers.
Although elderly patients have physiologic impairments in wound healing, their wounds should be expected to heal with the same frequency of closure as those in younger populations, albeit at a slower rate. However, compared to the general population, the elderly population has a higher incidence of chronic wounds: diabetic foot ulcers, pressure ulcers, and venous stasis ulcers. Experimental and...
متن کاملThe Effect of Bee Pollen on Healing of Pressure Ulcers in Diabetic Patients
Introduction: In recent years, there has been significant increase in the number of diabetic patients, the rate of hospitalization and non-traumatic lower limb amputation. The last two mentioned are known as the major complications of diabetes. In addition to it, there has been a considerable tendency among the medical therapist in applying apitherapy a branch of alternative medicine that dea...
متن کاملUse of Pressure Offloading Devices in Diabetic Foot Ulcers
OBJECTIVE Pressure mitigation is crucial for the healing of plantar diabetic foot ulcers. We therefore discuss characteristics and considerations associated with the use of offloading devices. RESEARCH DESIGN AND METHODS A diabetic foot ulcer management survey was sent to foot clinics in all 50 states and the District of Columbia in 2005. A total of 901 geographically diverse centers responde...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1413445112