Transcriptomics reveals the potential mechanism of ellagic acid extract from raspberry on wound healing

The aim of this study was to reveal the mechanism its wound healing function at molecular level using transcriptome sequencing technology. results showed that EAE mainly upregulated Cyclin A gene through AMPK signalling pathway, activated cell cycle promoted DNA synthesis, accelerated mitosis, and thus proliferation Human immortalized keratinocytes (HaCaT) cells. In addition, analysis downregulated enrichment revealed these genes were significantly or very enriched not only in cytokine-cytokine receptor interaction pathway but also TNF NF-κB inflammatory classical pathway. It downregulation such as Fn14, CCL2, CCL5, CARD14 LTB prevented responses while delaying apoptosis. provided important information for a basis further development functional products raspberry.