Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells
نویسندگان
چکیده
منابع مشابه
Synthesis of natural product-inspired compound libraries
An important aim in biology research is the elucidation of the role of proteins in complex, dynamic biological systems through the selective perturbation of their function. In contrast to genetic perturbations, chemical perturbations of protein function are conditional, acute, easily tuneable and reversible. [1] Furthermore, drug development still largely depends on the availability of bioactiv...
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UNLABELLED Therapeutic strategies for cancer treatment often remain challenging due to the cumulative risk derived from metastasis, which has been described as an aggressive state of cancer cell proliferation often resulting in failure of clinical therapy. In the current study, anti-metastatic properties of three chemotherapeutic drugs and three compounds from natural sources were investigated ...
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The popularization of genomic high-throughput technologies is causing a revolution in biomedical research and, particularly, is transforming the field of drug discovery. Systems biology offers a framework to understand the extensive human genetic heterogeneity revealed by genomic sequencing in the context of the network of functional, regulatory and physical protein-drug interactions. Thus, app...
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Natural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compli...
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References 1. Koch MA, Wittenberg LO, Basu S, Jeyaraj DA, Gourzoulidou E, Reinecke K, Odermatt A, Waldmann H: PNAS 2004, 101:16721-16726. 2. Koch MA, Schuffenhauer A, Scheck M, Wetzel S, Casaulta M, Odermatt A, Ertl P, Waldmann H: Charting biologically relevant chemical space: A structural classification of natural products (SCONP). PNAS 2005, 102:17272-17277. 3. Schuffenhauer A, Ertl P, Roggo ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0239551