Transcriptomic Network Interactions in Human Skin Treated with Topical Glucocorticoid Clobetasol Propionate
نویسندگان
چکیده
منابع مشابه
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate.
PURPOSE To compare histologically the action of Mitomycin C and that of Clobetasol propionate for surgical wound healing in rats. METHODS A circular skin fragment was surgically removed from 57 Wistar rats. Twenty-two animals were treated with Mitomycin C with topical medication in a single dose, 22 with Clobetasol propionate with a cream medication once a day for 15 days and 13 did not recei...
متن کاملObservations on the systemic effect of topical clobetasol propionate (Dermovate).
Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was suppressed when between 45 and 90 g was applied weekly. Insulin stress test results in patients with diseased skin showed an abnormally sma...
متن کاملBioequivalence assessment of topical clobetasol propionate products using visual and chromametric assessment of skin blanching.
PURPOSE The assessment of the degree of skin blanching following the application of a formulation containing a topical corticosteroid has been established as a surrogate method for the determination of bioequivalence. In this study, both visual and chromametric assessments have been carried out on two topical creams containing clobetasol propionate (0.05%) and the results from both methods are ...
متن کاملDifferent Approaches for Improving Skin Accumulation of Clobetasol-17-propionate
INTRODUCTION Topical glucocorticoids (TG) are the most frequently prescribed drugs by dermatologists. Their clinical effectiveness in the treatment of psoriasis and atopic dermatitis is related to their vasoconstrictive, anti-inflammatory, immunosuppressive and anti-proliferative effects. Despite their benefit in the therapy of inflammatory diseases, TG are associated number of side effects tha...
متن کاملEffect of Topical Steroid (0.05% Clobetasol Propionate) Treatment in Children With Severe Phimosis
PURPOSE We report our experience with the use of a topical steroid, 0.05% clobetasol propionate, for the treatment of phimosis with clinical complications. MATERIALS AND METHODS This was a retrospective analysis of the clinical outcomes of all patients presenting with phimosis to a single institution during the time period from October 2008 to May 2012. A total of 88 patients who had a Kikiro...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.04.021