Transcriptional Regulation ofFucosyltransferase 1Gene Expression in Colon Cancer Cells
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چکیده
منابع مشابه
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متن کاملTranscriptional Regulation of Fucosyltransferase 1 Gene Expression in Colon Cancer Cells
The α 1,2-fucosyltransferase I (FUT1) enzyme is important for the biosynthesis of H antigens, Lewis B, and Lewis Y. In this study, we clarified the transcriptional regulation of FUT1 in the DLD-1 colon cancer cell line, which has high expression of Lewis B and Lewis Y antigens, expresses the FUT1 gene, and shows α 1,2-fucosyltransferase (FUT) activity. 5'-rapid amplification of cDNA ends reveal...
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To determine the effect of nitric oxide (NO) on the cyclooxygenase-2 (COX-2) regulation in colon cancer cell lines we used the physiological NO donor GSNO. The proximal 6.6 kb of the COX-2 promoter was cloned into the pGL3 basic vector and the sequential deletion of the 6.6 kb COX-2 promoter generated promoter constructs of 4, 2.6, 1.9 and 0.9 kb. These constructs clearly show that the main reg...
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Pescadillo is a nucleolar protein that has been suggested to be involved in embryonic development and ribosome biogenesis. Deregulated expression of human pescadillo (PES1) was described in some tumors, but its precise roles in tumorigenesis remains unclear. In this study, we generated three monoclonal antibodies recognizing PES1 with high specificity and sensitivity, with which PES1 expression...
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ژورنال
عنوان ژورنال: The Scientific World Journal
سال: 2013
ISSN: 1537-744X
DOI: 10.1155/2013/105464