Transcriptional refractoriness is dependent on core promoter architecture
نویسندگان
چکیده
منابع مشابه
Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation.
The transcriptional regulation of a eukaryotic gene is specified by the interplay of specific regulatory factors, general transcription factors (GTFs), RNA polymerase II (Pol II), DNA sequence elements, and the chromatin structure of the promoter. The thousands of genes in a eukaryotic cell share a general transcriptional machinery and a common transcriptional pathway (Orphanides et al. 1996). ...
متن کاملPlatelet Refractoriness and how it is formed
Abstract Background and Objectives Transfusion of platelet has become one of the main treatments for thrombocytopenic patients to reduce the severity and frequency of bleeding consequences. Failure to attain the desired level of platelets in a patient following platelet transfusion is defined as platelet refractoriness. The purpose of present paper is to review and study the mechanisms involve...
متن کاملPromoter architecture and transcriptional regulation of Abf1-dependent ribosomal protein genes in Saccharomyces cerevisiae
In Saccharomyces cerevisiae, ribosomal protein gene (RPG) promoters display binding sites for either Rap1 or Abf1 transcription factors. Unlike Rap1-associated promoters, the small cohort of Abf1-dependent RPGs (Abf1-RPGs) has not been extensively investigated. We show that RPL3, RPL4B, RPP1A, RPS22B and RPS28A/B share a common promoter architecture, with an Abf1 site upstream of a conserved el...
متن کاملdesign a chimeric promoter containing survivin-like core promoter in order to transcriptional targeting of breast cancer
objective: the greatest challenge in cancer gene therapy is to achieve the high specificity and efficiency in targeting of cancer cells. because the goal of cancer gene therapy is to eradicate cancer cells, many therapeutic genes could be detrimental if unintentionally expressed in normal cells. using promoter of the genes which are expressed specifically in cancer cells or have much more expre...
متن کاملTranscriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences.
The idea that recruitment of the transcriptional machinery to a promoter suffices for gene activation is based partly on the results of "artificial recruitment" experiments performed in vivo. Artificial recruitment can be effected by a "nonclassical" activator comprising a DNA-binding domain fused to a component of the transcriptional machinery. Here we show that activation by artificial recrui...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2015
ISSN: 2041-1723
DOI: 10.1038/ncomms7753